US20060264716A1 - Microneedle with Glucose Sensor And Methods Thereof - Google Patents > 자유게시판

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Microneedle expertise offers a helpful minimally-invasive technique to sample blood. Resulting from their small dimension, at-home blood monitoring microneedles can pierce skin and take minute quantities of blood with minimal impact and or ache to the topic. In spite of their benefits, prior artwork microneedle programs are still somewhat invasive since they contain the extraction of blood from the patient. Implanted in vivo sensors provide another means to pattern blood chemistry that doesn't require at-home blood monitoring extraction. It would be fascinating to attain a much less invasive approach that would not extract blood from the patient and supply longer measurement times than in prior art in vivo units. This invention pertains to a microneedle with a glucose sensor. FIG. 3A is a perspective of an array of microneedles with glucose sensors in accordance with embodiments of the current invention. FIG. 4B is a aspect, cross-sectional view of a working microneedle. FIG. 4C is a facet view of one other array of microneedles in accordance with embodiments of the current invention.

10 area of a minimum of one of the needles which remains exposed to the conductive substrate and on at the least a portion of the conductive layer. 200 uM tall, 40 uM in diameter on the tip, and much wider at the base. In some embodiments, the wants are no wider at the base than the tip or they are solely considerably wider. Microneedles of this measurement have been shown to provide access to interstitial body fluid with out reaching the capillaries or nerves, so there is no such thing as a discomfort. This conductive layer is to cowl the needle and its rapid base, but not the tip or at-home blood monitoring the encompassing space, so that each needle has an unbiased electrical connection. These may very well be supplies like glucose oxidase for BloodVitals SPO2 the detection of glucose degree in interstitial fluids followed by a protecting layer to dam out common interferences. FIG. 1 reveals an isometric view and BloodVitals device FIG. 2 exhibits a section view to indicate the physical construction and layers.

FIGS. 3A-3B and FIGS. 4A-4C Rows of needles are shown connected collectively in FIGS. 3A-3B and BloodVitals SPO2 FIGS. 4A-4C , BloodVitals review but they is also individually sensed and inserted. Nafion or PTFE is utilized to dam frequent interferences. This results in the array of needles as proven in FIGS. This background worth can be used a baseline from which to measure the analyte of curiosity utilizing the working needles. Having a reference value and working values, permits a more delicate measurement, since the reference worth could be subtracted from or BloodVitals wearable divided into the working worth to successfully eliminate body fluid and environmental variations. Therefore, the spirit and scope of the appended claims should not be limited to the description of the popular variations contained herein. CROSS REFERENCE TO Related Applications - This software claims the benefit of U.S. Provisional Application No. 60/674,465 filed Apr. 25, at-home blood monitoring 2005, the entire disclosure of which is incorporated herein by reference. Government SPONSORSHIP - This invention was made with government assist underneath Grant NAG3-2744 awarded by NASA.

The government has certain rights in the invention. BACKGROUND - Microneedle expertise supplies a helpful minimally-invasive method to pattern blood. As a consequence of their small measurement, microneedles can pierce pores and at-home blood monitoring skin and take minute portions of blood with minimal influence and or ache to the topic. In spite of their advantages, at-home blood monitoring prior artwork microneedle programs are nonetheless somewhat invasive since they involve the extraction of blood from the patient. Implanted in vivo sensors provide one other means to pattern blood chemistry that doesn't require blood extraction. Unfortunately, in vivo sensors interact with the physiology and are prone to degradation during use. It would be fascinating to attain a less invasive strategy that would not extract blood from the affected person and supply longer measurement times than in prior art in vivo devices. Field OF THE INVENTION - This invention relates to a microneedle with a glucose sensor. FIG. 4C is a facet view of another array of microneedles in accordance with embodiments of the current invention.