Results: in the Bold-fMRI Procedure > 자유게시판

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Purpose: To elucidate the completely different neuromechanisms of topics with strabismic and anisometropic amblyopia in contrast with normal imaginative and prescient subjects utilizing blood oxygen stage-dependent functional magnetic resonance imaging (Bold-fMRI) and pattern-reversal visual evoked potential (PR-VEP). Methods: Fifty-three topics, age vary seven to 12 years, diagnosed with strabismic amblyopia (17 cases), anisometropic amblyopia (20 cases), and BloodVitals SPO2 device normal imaginative and prescient (16 instances), were examined using the Bold-fMRI and PR-VEP of UTAS-E3000 techniques. Cortical activation by binocular viewing of reversal checkerboard patterns was examined by way of the calcarine area of interest (ROI)-based mostly and spatial frequency-dependent evaluation. The correlation of cortical activation in fMRI and the P100 amplitude in VEP have been analyzed utilizing the SPSS 12.0 software bundle. Results: In the Bold-fMRI procedure, diminished areas and decreased activation ranges have been present in Brodmann area (BA) 17 and other extrastriate areas in topics with amblyopia compared with the traditional vision group. Usually, the decreased areas primarily resided in the striate visual cortex in subjects with anisometropic amblyopia.

In subjects with strabismic amblyopia, a extra vital cortical impairment was found in bilateral BA 18 and BA 19 than that in subjects with anisometropic amblyopia. The activation by excessive-spatial-frequency stimuli was decreased in bilateral BA 18 and 19 in addition to BA 17 in topics with anisometropic amblyopia, BloodVitals SPO2 whereas the activation was primarily decreased in BA 18 and BA 19 in subjects with strabismic amblyopia. These findings have been further confirmed by the ROI-based analysis of BA 17. During spatial frequency-dependent VEP detection, BloodVitals SPO2 topics with anisometropic amblyopia had diminished sensitivity for top spatial frequency in comparison with topics with strabismic amblyopia. The cortical activation in fMRI with the calcarine ROI-based analysis of BA 17 was significantly correlated with the P100 amplitude in VEP recording. Conclusions: This examine suggested that different types of amblyopia had completely different cortical responses and combinations of spatial frequency-dependent Bold-fMRI with PR-VEP may differentiate among various sorts of amblyopia in keeping with the different cortical responses. This study can supply new methods for amblyopia neurology study.

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