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Pulmonary embolism (PE) is the leading trigger of in-hospital loss of life and the third most frequent cause of cardiovascular demise. The clinical presentation of PE is variable, and selecting the appropriate therapy for particular person patients could be difficult. Historically, remedy of PE has involved a selection of anticoagulation, thrombolysis or surgery; nevertheless, a range of percutaneous interventional technologies have been developed which can be under investigation in patients with intermediate-high-danger or high-danger PE. These interventional applied sciences embrace catheter-directed thrombolysis (with or with out ultrasound assistance), aspiration thrombectomy and mixtures of the aforementioned rules. These interventional remedy options may lead to a more speedy improvement in proper ventricular function and pulmonary and/or systemic haemodynamics specifically patients.