Cannabinoid Receptor 1
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According to the variable expression of each excitatory glutamate and inhibitory GABA interneurons in each the basal ganglia's direct and indirect motor loops, synthetic cannabinoids are identified to affect this system in a dose-dependent triphasic sample. The CB1 receptor shares the construction characteristic of all G-protein-coupled receptors, possessing seven transmembrane domains connected by three extracellular and three intracellular loops, an extracellular N-terminal tail, and an intracellular C-terminal tail.
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According to the variable expression of each excitatory glutamate and inhibitory GABA interneurons in each the basal ganglia's direct and indirect motor loops, synthetic cannabinoids are identified to affect this system in a dose-dependent triphasic sample. The CB1 receptor shares the construction characteristic of all G-protein-coupled receptors, possessing seven transmembrane domains connected by three extracellular and three intracellular loops, an extracellular N-terminal tail, and an intracellular C-terminal tail.
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