A Wireless Patch for the Monitoring of C-reactive Protein in Sweat > 자유게시판

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The quantification of protein biomarkers in blood at picomolar-degree sensitivity requires labour-intensive incubation and washing steps. Sensing proteins in sweat, which would allow for level-of-care monitoring, is hindered by the typically giant interpersonal and intrapersonal variations in its composition. Here we report the design and efficiency of a wearable and wireless patch for the real-time electrochemical detection of the inflammatory biomarker C-reactive (CRP) protein in sweat. The gadget integrates iontophoretic sweat extraction, microfluidic channels for sweat sampling and for reagent routing and alternative, and a graphene-primarily based sensor array for quantifying CRP (via an electrode functionalized with anti-CRP capture antibodies-conjugated gold nanoparticles), ionic energy, pH and temperature for the real-time calibration of the CRP sensor. In patients with chronic obstructive pulmonary disease, with active or previous infections or who had heart failure, the elevated concentrations of CRP measured through the patch correlated effectively with the protein’s levels in serum. Wearable biosensors for the true-time sensitive evaluation of inflammatory proteins in sweat could facilitate the administration of chronic diseases.

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