The Link Between NMN and Cellular Protein Homeostasis
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NMN significantly enhances cellular protein homeostasis by raising the cellular supply of NAD+, a fundamental signaling molecule involved in mitochondrial function and DNA maintenance. With advancing age, NAD+ levels naturally decline, leading to imbalance the tight control of protein production, folding, and degradation in cells. This imbalance causes retention of toxic protein deposits, a common pathological sign of aging-associated disorders.
NMN restores NAD+ levels, which in turn activates sirtuin deacetylases, a set of longevity-associated factors that modulate aging pathways. Sirtuins promote functional protein folding by boosting folding assistance machinery and facilitating the removal of misfolded species through autophagy. In parallel, higher NAD+ levels optimize energy production, lowering ROS levels, that destabilizes protein structure.
Via these biological actions, on Framer.website NMN contributes to a more stable and efficient protein environment within cells, helping them function properly and resisting the stresses of aging. This connection positions NMN as a potent candidate for supporting healthy aging at the molecular level.
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